![]() ![]() Some automated analyzers use MPV and PLT to calculate PCT as an estimate of platelet mass analogous to the hematocrit (HCT) as a measure of red cell mass. Three parameters of interest are the mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT). New laser-based hematology analyzers generate platelet data beyond a platelet count (PLT) that may be clinically useful in evaluating thrombocytopenia. 4, 5 In addition to developing better diagnostic approaches to IMT, there is a clinical need for accurate monitoring of primary hemostatic competence. 3 Unfortunately, this testing is not widely available, and although very sensitive, may lack specificity especially for primary IMT in dogs, 2 as in human patients. 2 Because the pathogenesis involves the adherence of antiplatelet antibodies to antigens on the platelet surface, the detection of platelet-bound antibodies may confirm an immune-mediated pathogenesis for the disease. A diagnosis of primary IMT is established by excluding other causes of thrombocytopenia. 1 The disease may be primary or can occur secondary to a variety of inflammatory or neoplastic conditions. Immune-mediated thrombocytopenia (IMT) is the most common cause of severe thrombocytopenia in dogs. Time to achieve a threshold PCT tended to be shorter than PLT, suggesting that PCT may be a useful platelet parameter for monitoring dogs with IMT. Immune-mediated thrombocytopenia is characterized by increased MPV. The median time for PCT to reach threshold in confirmed responders was faster (3 days) compared with PLT (4 days). The PDW was not significantly different among the groups. Mean platelet volume was higher in IMT dogs (17.3 fl) than the reference population (10.5 fl) ( P < .0001). The PCT equivalent to a PLT of 75,000/μL (assuming an average MPV) was calculated for comparison with PLT in terms of time to achieve a threshold of platelet mass by the 2 measures. Fifteen were confirmed to have attained a PLT ≥ 75,000/μL on at least 1 CBC within 15 days after admission. MethodsĬase-control retrospective study PLT, PCT, MPV, and platelet distribution width (PDW) were recorded from CBCs from 49 dogs, with 45 having data collected on the day of presentation. Animalsįorty-nine dogs with automated PLT < 30,000/μL because of presumed primary IMT and hematocrit (HCT), PCT, MPV, and platelet distribution width determined from the same complete blood count (CBC), and 46 healthy controls. Hypothesis/Objectivesĭogs with presumed primary IMT will have increased MPV, and therefore platelet mass (PCT) will increase faster than platelet count (PLT) during recovery. These indices may provide clinically valuable information in acquired thrombocytopenia. When your RDW value is below the limits, you shouldn’t worry because any tiny error in the testing procedures can result in such a falsely low result and can’t indicate a disease or a medical issue, and it’s beneficial to know that Low RDW value doesn’t necessarily mean that red blood cells are all in the small size, but the normal RDW is a more significant indicator of single size RBCs.Mean platelet volume (MPV) and plateletcrit (PCT) are indices used in evaluating immune-mediated thrombocytopenia (IMT) in humans and in dogs with congenital macrothrombocytopenia. ![]() ![]() thalassemia).ĭoes low RDW a valid indicator in diagnosis of anemia? The reference range for RDW readings (11.5 – 14.5): doesn’t mean it is normal when your RDW lye inside this range, rather the RDW values within the reference range mean either normal size variation without anemia or means anemia with single size RBCs (i.e.The “L” letter beside the RDW value: means “low” as usually represented in the medical reports, Low RDW than the reference limits is medically insignificant because of inaccurate blood cell automatic counting or due to sampling errors or other hidden unattended errors in the procedures, thus why many clinicians don’t rely on RDW values.High RDW appears when you have anemia due to iron deficiency, medically (a type of microcytic hypochromic anemia). The thalassemia trait doesn’t elevate RDW and still be normal, that why the normal RDW doesn’t exclude anemia. RDW: is a shortcode of the medical term “Red-blood-cell Distribution Width”, RDW represents the degree of variation of the sizes of red blood cells inside human blood, the normal range of RDW is 11.5% up to 14.5%,.This screenshot of a RDW value in a CBC report shows: Many blood count tests today write the RDW as a part of the CBC test results, as below picture: ![]()
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